Functional Anatomy of T Cell Activation and Synapse Formation
نویسندگان
چکیده
منابع مشابه
Functional anatomy of T cell activation and synapse formation.
T cell activation and function require a structured engagement of antigen-presenting cells. These cell contacts are characterized by two distinct dynamics in vivo: transient contacts resulting from promigratory junctions called immunological kinapses or prolonged contacts from stable junctions called immunological synapses. Kinapses operate in the steady state to allow referencing to self-pepti...
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T cell activation is based on interactions of T cell antigen receptors with MHC-peptide complexes in a specialized cell-cell junction between the T cell and antigen-presenting cell-the immunological synapse. The immunological synapse coordinates naïve T cell activation and migration by stopping T cell migration with antigen-presenting cells bearing appropriate major histocompatibility complex (...
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ژورنال
عنوان ژورنال: Annual Review of Immunology
سال: 2010
ISSN: 0732-0582,1545-3278
DOI: 10.1146/annurev-immunol-030409-101308